A0183

Acyclovir

CAS number 59277-89-3
Molecular weight C8H11N5O3 = 225.2

Acyclovir inhibits viral DNA synthesis by selective interaction with two distinct viral proteins. Cellular uptake and initial phosphorylation are facilitated by thymidine kinase. Cellular enzymes convert the monophosphate to acyclovir triphosphate and compete for endogeneous deoxyguanosine triphos-phate (dGTP). Acyclovir triphosphate competively inhibits viral DNA polymerases and, to a much smaller extent, cellular DNA polymerases. Acyclovir triphosphate is also incorporated into viral DNA, where it acts as a chain terminator because of the lack of 3’-hydroxyl group. By a mechanism termed suicide inactivation, the terminated DNA template containing acyclovir binds the enzym and leads to irreversible inactivation of the DNA polymerase.

Storage condition

  • Store at room temperature
Filename Language File size
A0183_GB.pdf English 139 KB
A0183_NL.pdf Nederlands 142 KB
A0183_DE.pdf Deutsch 146 KB
A0183_FR.pdf Français 143 KB
A0183_ES.pdf Español 143 KB
A0183_IT.pdf Italiano 141 KB
Filename Batch number Expiry date Language
A0183_012837_GB.pdf 012837 03-2019 English
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  • A0183.1000
  • 1 g
  • € 55.90
  • Order
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