CAS number 59-05-2
Molecular weight C20H22N8O5 = 454.4

An antineoplastic agent that acts as an anti-metabolite of folic acid. Within the cell folic acid is reduced to dihydrofolic and tetrahydrofolic acid. Methotrexate competitively inhibits the enzyme dihydrofolate reductase and prevents the formation of tetrahydrofolate, which is necessary for purine and pyrimidine synthesis and consequently the formation of DNA and RNA. Most active against cells in the S phase.

Storage condition

  • Store dry at room temperature
  • Soluble in alkaline solutions
  • Protect from light

Hazard statements

  • H301 Toxic if swallowed
  • H315 Causes skin irritation
  • H319 Causes serious eye irritation
  • H340 May cause genetic defects
  • H351 Suspected of causing cancer
  • H360 May damage fertility or the unborn child

Precautionary statements

  • P201 Obtain special instructions before use
  • P280 Wear protective gloves/protective clothing/eye protection/face protection
  • P308 IF exposed or concerned:
  • P313 Get medical advice/attention
Filename Language File size
M0130_GB.pdf English 175 KB
M0130_NL.pdf Nederlands 180 KB
M0130_DE.pdf Deutsch 184 KB
M0130_FR.pdf Français 183 KB
M0130_ES.pdf Español 182 KB
M0130_IT.pdf Italiano 180 KB
Filename Batch number Expiry date Language
M0130_016113_GB.pdf 016113 12-2022 English
M0130_014273_GB.pdf 014273 11-2021 English
M0130_014369_GB.pdf 014369 11-2021 English
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  • M0130.0001
  • 1 g
  • € 93.50
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